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Items: 18

1.

The Genetic Architecture of Dietary Iron Overload and Associated Pathology in Mice

(Submitter supplied) Tissue iron (Fe) overload is a frequent pathologic finding in multiple disease states including non-alcoholic fatty liver disease (NAFLD), neurodegenerative disorders, cardiomyopathy, diabetes, and some forms of cancer. The role of iron, as a cause or consequence of disease progression and observed phenotypic manifestations, remains controversial. In addition, the impact of genetic variation on iron overload related phenotypes is unclear, and the identification of genetic modifiers is incomplete. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
127 Samples
Download data: TXT
Series
Accession:
GSE230674
ID:
200230674
2.

Conserved multitissue transcriptomic adaptations to exercise training in humans and mice

(Submitter supplied) Physical activity is associated with beneficial adaptations in human and rodent metabolism. We studied over 50 complex traits before and after exercise intervention in middle-aged men and a panel of 100 diverse strains of female mice. Candidate gene analyses in three brain regions, muscle, liver, heart, and adipose tissue of mice revealed genetic drivers of clinically relevant traits including volitional exercise volume, muscle metabolism, adiposity, and hepatic lipids. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21493 GPL24247
499 Samples
Download data: TXT
Series
Accession:
GSE230102
ID:
200230102
3.

Heart profiling in HMDP (high-fat/high-sucrose diet)

(Submitter supplied) Identify genes in the heart whose expression is under genetic regulation in the Hybrid Mouse Diversity Panel (HMDP). The HMDP comprises classical inbred and recombinant inbred wild type mice. The TPM values of genes were used for genome wide association. These data are used to identify candidate genes at loci associated with cardiovascular traits.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
187 Samples
Download data: TXT
Series
Accession:
GSE194198
ID:
200194198
4.

Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice

(Submitter supplied) Heritable epigenetic factors can contribute to complex disease etiology. In this study we examine, on a global scale, the contribution of DNA methylation to complex traits that are precursors to heart disease, diabetes and osteoporosis. We profiled DNA methylation patterns in the liver using bisulfite sequencing in 90 mouse inbred strains, genome-wide expression levels, proteomics, metabolomics and sixty-eight clinical traits, and performed epigenome-wide association studies (EWAS). more...
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL13112
105 Samples
Download data: CGMAP
Series
Accession:
GSE67507
ID:
200067507
5.

M0058

Organism:
Mus musculus
Source name:
liver
Platform:
GPL21103
Series:
GSE230674
Download data
Sample
Accession:
GSM7230985
ID:
307230985
6.

48_7_BAT

Organism:
Mus musculus
Source name:
brown adipose tissue
Platform:
GPL24247
Series:
GSE230102
Download data
Sample
Accession:
GSM7187444
ID:
307187444
7.

48_1_BAT

Organism:
Mus musculus
Source name:
brown adipose tissue
Platform:
GPL24247
Series:
GSE230102
Download data
Sample
Accession:
GSM7187443
ID:
307187443
8.

48_7_quadriceps

Organism:
Mus musculus
Source name:
quadriceps
Platform:
GPL21493
Series:
GSE230102
Download data
Sample
Accession:
GSM7187344
ID:
307187344
9.

48_1_quadriceps

Organism:
Mus musculus
Source name:
quadriceps
Platform:
GPL21493
Series:
GSE230102
Download data
Sample
Accession:
GSM7187343
ID:
307187343
10.

48_7_liver

Organism:
Mus musculus
Source name:
liver
Platform:
GPL21493
Series:
GSE230102
Download data
Sample
Accession:
GSM7187245
ID:
307187245
11.

48_1_liver

Organism:
Mus musculus
Source name:
liver
Platform:
GPL21493
Series:
GSE230102
Download data
Sample
Accession:
GSM7187244
ID:
307187244
12.

48_7_heart

Organism:
Mus musculus
Source name:
heart
Platform:
GPL21493
Series:
GSE230102
Download data
Sample
Accession:
GSM7187145
ID:
307187145
13.

48_1_heart

Organism:
Mus musculus
Source name:
heart
Platform:
GPL21493
Series:
GSE230102
Download data
Sample
Accession:
GSM7187144
ID:
307187144
14.

48_7_gWAT

Organism:
Mus musculus
Source name:
gonadal white adipose tissue
Platform:
GPL21493
Series:
GSE230102
Download data
Sample
Accession:
GSM7187045
ID:
307187045
15.

48_1_gWAT

Organism:
Mus musculus
Source name:
gonadal white adipose tissue
Platform:
GPL21493
Series:
GSE230102
Download data
Sample
Accession:
GSM7187044
ID:
307187044
16.

heart: 103

Organism:
Mus musculus
Source name:
BTBR T<+> tf/J_F
Platform:
GPL24247
Series:
GSE194198
Download data
Sample
Accession:
GSM5830493
ID:
305830493
17.

heart: 100

Organism:
Mus musculus
Source name:
BTBR T<+> tf/J_M
Platform:
GPL24247
Series:
GSE194198
Download data
Sample
Accession:
GSM5830492
ID:
305830492
18.

S74NR

Organism:
Mus musculus
Source name:
Liver
Platform:
GPL13112
Series:
GSE67507
Download data: CGMAP
Sample
Accession:
GSM1648302
ID:
301648302
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